The country recorded 100,762 new cases and and 453 new deaths as of 9:30 p.m. ET on Sunday, marking the fifth highest day of new cases in the country since the pandemic began.
The fall resurgence has brought regular records in cases, people hospitalized and daily deaths -- and experts are encouraging measures to mitigate the spread as they warn that the numbers may continue to climb in coming weeks.
"We're going to see these case numbers really start to explode," former US Food and Drug Administration Commissioner Dr. Scott Gottlieb told CNBC on Friday.
The virus can be dealt with by targeting mitigation state by state, he said, but the US is not doing that currently, and the lack of intervention could build up for the future, spelling trouble for December and January, he said.
"It's not just the cases; it's the hospitalizations as well. That's really the number to watch: 53,000 people hospitalized, 10,500 people in ICUs. That's a lot, and it's growing very quickly."
Sixteen states reported record high Covid-19 hospitalizations Friday, according to the Covid Tracking Project, and 22 states have reported at least one record high day of coronavirus hospitalizations during November, so far.
On Sunday morning, the global number of cases topped 50 million, with the US, India, Brazil and Russia, in that order, the hardest hit, composing more than half the cases, Johns Hopkins reports.
While the total number of cases in the US approaches 10 million, Texas alone is inching toward 1 million cases, with more than 5,000 reported Sunday.
In Oregon, Gov. Kate Brown said Sunday the state has surpassed the "alarming threshold" of 50,000 cases.
Fauci: stick with science, not politics
The pandemic will soon become the primary concern of President-elect Joe Biden. He plans to announce a 12-person coronavirus task force Monday, two sources with knowledge of the announcement told CNN.
Biden's task force will be headed by three co-chairs, including former Surgeon General Dr. Vivek Murthy, former Food and Drug Administration Commissioner Dr. David Kessler and Yale University's Dr. Marcella Nunez-Smith.
Gottlieb told CBS that Biden will be taking the helm at the "apex" of the pandemic.
Dr. Megan Ranney, an emergency physician at Brown University, said she's optimistic about Biden's transition plans for leading the country's response, but said the virus will "have already run rampant through communities across the United States" by the time he takes office.
"We're just heading into the very worst of this pandemic," Ranney told CNN's Fredricka Whitfield, adding that she is concerned about the expected social gatherings during late November and early December.
"We're about to see all of these little epidemics across the country, crossed and mixed, and it's going to be an awful lot like pouring gasoline on a fire," she said.
In a virtual event with the American Medical Association on Saturday, Dr. Anthony Fauci, director of the Institute for Allergy and Infectious Diseases, advised physicians in leadership roles to stick with science, evidence and data when it comes to making coronavirus recommendations.
"Stay completely apolitical. Don't get involved in any of the political aspects, and just focus on what your job is as a scientist and a physician," Fauci said. "You do that, you'll be fine."
Health experts have been working to combat skepticism around coronavirus vaccines and recommendations after being at odds at times with political leaders.
Gottlieb said Sunday that President Donald Trump's administration needs a more aggressive strategy to combat coronavirus between now and January. And he suggested during a CBS interview that Biden should work with the National Governors Association to formulate national policy and "coordinate across the different states so it starts to have the semblance of a more cohesive plan."
"We've been sort of arguing politically over what I think is a false dichotomy, and that it's really a choice between lockdowns and no lockdowns and that's not the case," Gottlieb told "Face the Nation."
"We're not going to get perfect control over this virus -- it's a contagious virus. It's going to spread, but it doesn't need to spread at the levels and at the velocity that's going to start to press the healthcare system, which is what we're seeing," he told the show.
The Biden transition team listed the pandemic as the first item on its website, pledging free, reliable testing, more protective equipment, clear guidance, restored relations with the World Health Organization and a $25 billion plan to manufacture and distribute a vaccine. Vice President-elect Kamala Harris will head a task force to tackle racial and ethnic disparities revealed during the pandemic.
The team also promises a mask mandate but says it will get there by working with governors and mayors and "by asking the American people to do what they do best: Step up in a time of crisis."
'Age, experience and better drugs' impact death rate
Though the death toll has climbed, the rate of cases that have resulted in fatalities has seemingly decreased, and Fauci said that is due to "age, experience and better drugs."
As with all diseases, health professionals learn more about the virus as it goes on, including when to put people on ventilators, Fauci said Saturday.
"We just get better at treating people," he said. "You (know) what works. You know what doesn't work, including just fundamental, nonpharmacological approaches."
The use of treatments that can help people, such as dexamethasone and remdesivir, has also further developed, he said.
Also impacting the death rate are the college students going back to school and being infected more, he said. Those getting infected now compared with the spring "is almost a decade difference of being younger now."
"Ultimately, they're going to wind up infecting people in the community, but they're the ones that are sort of driving the infection," Fauci said.
Covid symptoms last 'well beyond' expectation
As researchers learn more about the virus, they're noticing that the impacts can drag on, Fauci said.
Some patients have reported symptoms lasting even after they have tested negative from a coronavirus infection.
"We do know for absolutely certain that there is a post-Covid-19 syndrome -- referred to sometimes as long Covid, chronic Covid, long haulers," Fauci said during the AMA event.
"We're seeing variable percentages, and anywhere from 25 to 35% or more have lingering symptoms -- well beyond what you'd expect post any viral syndrome, like influenza and others," he said.
Symptoms include fatigue, shortness of breath, muscle aches, sleep disturbances and what is referred to as "brain fog."
"So, there's no doubt that it's going on, that (it) can last anywhere from weeks to months," he said, adding that it could be longer, but that isn't known because the novel virus was discovered less than a year ago.
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